MicroRNA-122: a therapeutic target for hepatitis C virus (HCV) infection.
Publication/Presentation Date
6-1-2011
Abstract
Hepatitis C virus infection is the main cause of liver disease worldwide, often leading to chronic hepatitis. Recent studies have demonstrated that miRNA-122, a liver-specific miRNA, is required for HCV replication in hepatocytes by its binding to the 5' UTR of HCV. Down-regulation of miRNA-122 in vitro and in vivo has led to significant inhibition of viral replication. In the present article, we report the major recent findings on the potential therapeutic role of anti-miRNA-122 molecules.
Volume
3
Issue
3
First Page
1032
Last Page
1037
ISSN
1945-0524
Published In/Presented At
Nunnari, G., & Schnell, M. J. (2011). MicroRNA-122: a therapeutic target for hepatitis C virus (HCV) infection. Frontiers in bioscience (Scholar edition), 3(3), 1032–1037. https://doi.org/10.2741/207
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21622252
Department(s)
Administration and Leadership
Document Type
Article