Keeping it in check: chronic viral infection and antiviral immunity in the brain.
Publication/Presentation Date
12-1-2016
Abstract
It is becoming clear that the manner by which the immune response resolves or contains infection by a pathogen varies according to the tissue that is affected. Unlike many peripheral cell types, CNS neurons are generally non-renewable. Thus, the cytolytic and inflammatory strategies that are effective in controlling infections in the periphery could be damaging if deployed in the CNS. Perhaps for this reason, the immune response to some CNS viral infections favours maintenance of neuronal integrity and non-neurolytic viral control. This modified immune response - when combined with the unique anatomy and physiology of the CNS - provides an ideal environment for the maintenance of viral genomes, including those of RNA viruses. Therefore, it is possible that such viruses can reactivate long after initial viral exposure, contributing to CNS disease.
Volume
17
Issue
12
First Page
766
Last Page
776
ISSN
1471-0048
Published In/Presented At
Miller, K. D., Schnell, M. J., & Rall, G. F. (2016). Keeping it in check: chronic viral infection and antiviral immunity in the brain. Nature reviews. Neuroscience, 17(12), 766–776. https://doi.org/10.1038/nrn.2016.140
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
27811921
Department(s)
Administration and Leadership
Document Type
Article