Rhabdoviruses as vectors for vaccines and therapeutics.
Publication/Presentation Date
10-1-2020
Abstract
Appropriate choice of vaccine vector is crucial for effective vaccine development. Rhabdoviral vectors, such as rabies virus and vesicular stomatitis virus, have been used in a variety of vaccine strategies. These viruses have small, easily manipulated genomes that can stably express foreign glycoproteins due to a well-established reverse genetics system for virus recovery. Both viruses have well-described safety profiles and have been demonstrated to be effective vaccine vectors. This review will describe how these Rhabdoviruses can be manipulated for use as vectors, their various applications as vaccines or therapeutics, and the advantages and disadvantages of their use.
Volume
44
First Page
169
Last Page
182
ISSN
1879-6265
Published In/Presented At
Scher, G., & Schnell, M. J. (2020). Rhabdoviruses as vectors for vaccines and therapeutics. Current opinion in virology, 44, 169–182. https://doi.org/10.1016/j.coviro.2020.09.003
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33130500
Department(s)
Administration and Leadership
Document Type
Article