Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle.

Authors

• Nir Paran
• Christoph Wirblich
• Catherine Olal
• Alessandro Tarquinio
• Kimberly H Lohmeyer
• Drishya Kurup
• Stacey Schultz-Cherry
• Ismaila Shittu
• Gregory C Gray
• Dennis A Bente
• Pia U Olafson
• Matthias J Schnell

Publication/Presentation Date

8-19-2025

Abstract

The circulation of highly pathogenic H5 influenza A viruses in cattle, other mammals, and wildlife threatens animal and human health. To address this, we vaccinated heifer-calves with a deactivated rabies-virus-based H5 vaccine, which was well-tolerated and elicited neutralizing antibodies against both clade-1 and clade-2.3.4.4b H5N1 viruses, comparable to naturally H5-infected and convalescing cows. The immune responses to the vaccine platform were durable for at least 200 days and unaffected by preexisting RABV immunity.

Volume

10

Issue

1

First Page

197

Last Page

197

ISSN

2059-0105

Published In/Presented At

Paran, N., Wirblich, C., Olal, C., Tarquinio, A., Lohmeyer, K. H., Kurup, D., Schultz-Cherry, S., Shittu, I., Gray, G. C., Bente, D. A., Olafson, P. U., & Schnell, M. J. (2025). Immunogenicity and safety of a rabies-based highly pathogenic influenza A virus H5 vaccine in cattle. NPJ vaccines, 10(1), 197. https://doi.org/10.1038/s41541-025-01238-2

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

40830096

Department(s)

Administration and Leadership

Document Type

Article