Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.

Authors

• Benjamin M Davis
• Volker Fensterl
• Tessa M Lawrence
• Andrew W Hudacek
• Ganes C Sen
• Matthias J Schnell

Publication/Presentation Date

9-1-2017

Abstract

Understanding the interactions between rabies virus (RABV) and individual host cell proteins is critical for the development of targeted therapies. Here we report that interferon-induced protein with tetratricopeptide repeats 2 (Ifit2), an interferon-stimulated gene (ISG) with possible RNA-binding capacity, is an important restriction factor for rabies virus. When Ifit2 was depleted, RABV grew more quickly in mouse neuroblastoma cells

Volume

91

Issue

17

ISSN

1098-5514

Published In/Presented At

Davis, B. M., Fensterl, V., Lawrence, T. M., Hudacek, A. W., Sen, G. C., & Schnell, M. J. (2017). Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity. Journal of virology, 91(17), e00889-17. https://doi.org/10.1128/JVI.00889-17

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

28637751

Department(s)

Administration and Leadership

Document Type

Article