The spread and evolution of rabies virus: conquering new frontiers.
Publication/Presentation Date
4-1-2018
Abstract
Rabies is a lethal zoonotic disease that is caused by lyssaviruses, most often rabies virus. Despite control efforts, sporadic outbreaks in wildlife populations are largely unpredictable, underscoring our incomplete knowledge of what governs viral transmission and spread in reservoir hosts. Furthermore, the evolutionary history of rabies virus and related lyssaviruses remains largely unclear. Robust surveillance efforts combined with diagnostics and disease modelling are now providing insights into the epidemiology and evolution of rabies virus. The immune status of the host, the nature of exposure and strain differences all clearly influence infection and transmission dynamics. In this Review, we focus on rabies virus infections in the wildlife and synthesize current knowledge in the rapidly advancing fields of rabies virus epidemiology and evolution, and advocate for multidisciplinary approaches to advance our understanding of this disease.
Volume
16
Issue
4
First Page
241
Last Page
255
ISSN
1740-1534
Published In/Presented At
Fisher, C. R., Streicker, D. G., & Schnell, M. J. (2018). The spread and evolution of rabies virus: conquering new frontiers. Nature reviews. Microbiology, 16(4), 241–255. https://doi.org/10.1038/nrmicro.2018.11
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
29479072
Department(s)
Administration and Leadership
Document Type
Article