Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways.

Authors

• A H Hoon
• W T Lawrie
• E R Melhem
• E M Reinhardt
• P C M Van Zijl
• M Solaiyappan
• H Jiang
• M V Johnston
• S Mori

Publication/Presentation Date

9-10-2002

Abstract

The authors used diffusion-tensor imaging to examine central white matter pathways in two children with spastic quadriplegic cerebral palsy. Corticospinal tracts projecting from cortex to brainstem resembled controls. In contrast, posterior regions of the corpus callosum, internal capsule, and corona radiata were markedly reduced, primarily in white matter fibers connected to sensory cortex. These findings suggest that the motor impairment in periventricular leukomalacia may, in part, reflect disruption of sensory connections outside classic pyramidal motor pathways.

Volume

59

Issue

5

First Page

752

Last Page

756

ISSN

0028-3878

Published In/Presented At

Hoon, A. H., Jr, Lawrie, W. T., Jr, Melhem, E. R., Reinhardt, E. M., Van Zijl, P. C., Solaiyappan, M., Jiang, H., Johnston, M. V., & Mori, S. (2002). Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways. Neurology, 59(5), 752–756. https://doi.org/10.1212/wnl.59.5.752

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

12221171

Department(s)

Administration and Leadership

Document Type

Article