Neuroimaging in amyotrophic lateral sclerosis.
Publication/Presentation Date
1-1-2011
Abstract
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive degeneration of upper motor neurons (UMN) and lower motor neurons (LMN). While LMN dysfunction can be confirmed by electromyography (EMG) and muscle biopsy, UMN involvement is more difficult to detect, particularly in the early phase. Objective and sensitive measures of UMN dysfunction are needed for early diagnosis and monitoring of disease progression and therapeutic efficacy. Advanced magnetic resonance imaging (MRI) techniques, such as diffusion, perfusion, magnetization transfer imaging, functional MRI, and MR spectroscopy, provide insight into the pathophysiological processes of ALS and may have a role in the identification and monitoring of UMN pathology. This article provides an overview of these neuroimaging techniques and their potential roles in ALS.
Volume
8
Issue
1
First Page
63
Last Page
71
ISSN
1878-7479
Published In/Presented At
Wang, S., Melhem, E. R., Poptani, H., & Woo, J. H. (2011). Neuroimaging in amyotrophic lateral sclerosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 8(1), 63–71. https://doi.org/10.1007/s13311-010-0011-3
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21274686
Department(s)
Administration and Leadership
Document Type
Article