Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation.

Authors

• D Ellenberg
• J Shi
• S Jain
• J-H Chang
• H Ripps
• S Brady
• E R Melhem
• F Lakkis
• A Adamis
• D-F Chen
• R Ellis-Behnke
• R S Langer
• S M Strittmatter
• D T Azar

Publication/Presentation Date

9-1-2009

Abstract

Maintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation.

Volume

93

Issue

9

First Page

1134

Last Page

1140

ISSN

1468-2079

Published In/Presented At

Ellenberg, D., Shi, J., Jain, S., Chang, J. H., Ripps, H., Brady, S., Melhem, E. R., Lakkis, F., Adamis, A., Chen, D. F., Ellis-Behnke, R., Langer, R. S., Strittmatter, S. M., & Azar, D. T. (2009). Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation. The British journal of ophthalmology, 93(9), 1134–1140. https://doi.org/10.1136/bjo.2008.155267

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

19286686

Department(s)

Administration and Leadership

Document Type

Article