Quantifying blood-brain barrier permeability in patients with ischemic stroke using non-contrast MRI.
Publication/Presentation Date
6-1-2024
Abstract
Increased blood-brain barrier permeability (BBBP) after ischemic stroke predisposes patients to hemorrhagic conversion. While altered BBBP can impact patient recovery, it is not routinely assessed during the workup of acute ischemic stroke (AIS). We study the effectiveness of the non-contrast MRI sequences diffusion-prepared pseudocontinuous arterial spin labeling (DP-pCASL) and Neurite Orientation Dispersion and Density Imaging (NODDI) in assessing BBBP and correlating to tissue microstructure after ischemic insult. Twelve patients with AIS were prospectively enrolled to undergo our multimodal MR imaging, which generated the DP-pCASL-derived cerebral blood flow (CBF), arterial transit time (ATT), and water exchange rate (k
Volume
109
First Page
165
Last Page
172
ISSN
1873-5894
Published In/Presented At
Mouchtouris, N., Ailes, I., Gooch, R., Raimondo, C., Oghli, Y. S., Tjoumakaris, S., Jabbour, P., Rosenwasser, R., & Alizadeh, M. (2024). Quantifying blood-brain barrier permeability in patients with ischemic stroke using non-contrast MRI. Magnetic resonance imaging, 109, 165–172. https://doi.org/10.1016/j.mri.2024.03.027
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
38513785
Department(s)
Administration and Leadership
Document Type
Article