High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophrenia.

Authors

• Juan R Bustillo
• Laura M Rowland
• John Lauriello
• Helen Petropoulos
• Roger Hammond
• Blaine Hart
• William M Brooks

Publication/Presentation Date

1-1-2002

Abstract

OBJECTIVE: Proton magnetic resonance spectroscopy ((1)H-MRS) studies of medicated patients with schizophrenia suggest high choline levels in the caudate nucleus. However, assessments of antipsychotic-naive patients are needed.

METHOD: The authors studied 11 antipsychotic-naive schizophrenia patients and 11 normal comparison subjects with single-voxel (1)H-MRS of the left caudate nucleus. Concentrations of N-acetylaspartate, choline, and creatine were determined and corrected for the proportion of cerebrospinal fluid in the voxel.

RESULTS: The patients with schizophrenia had significantly higher levels of choline than the comparison subjects, while the other two metabolites did not differ between groups.

CONCLUSIONS: High caudate choline levels in schizophrenia are not secondary to antipsychotic treatment.

Volume

159

Issue

1

First Page

130

Last Page

133

ISSN

0002-953X

Published In/Presented At

Bustillo, J. R., Rowland, L. M., Lauriello, J., Petropoulos, H., Hammond, R., Hart, B., & Brooks, W. M. (2002). High choline concentrations in the caudate nucleus in antipsychotic-naive patients with schizophrenia. The American journal of psychiatry, 159(1), 130–133. https://doi.org/10.1176/appi.ajp.159.1.130

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

11772701

Department(s)

Administration and Leadership

Document Type

Article