Sildenafil for iatrogenic serotonergic antidepressant medication-induced sexual dysfunction in 4 patients.
Publication/Presentation Date
1-1-1999
Abstract
OBJECTIVE: To evaluate the effect of sildenafil on iatrogenic serotonergic antidepressant-induced sexual dysfunction.
METHOD: Four outpatients (2 men, 2 women) who developed sexual dysfunction (erectile impotence, anorgasmia) during treatment with a serotonin reuptake inhibitor antidepressant for psychiatric disorder were selected. Each subject was initially prescribed sildenafil 50 mg to be taken approximately 1 hour before sexual activity. The dose was increased to 100 mg for a partial or failed response.
RESULTS: Four cases are detailed in case report fashion. All 4 had rapid reversal of their sexual dysfunction, usually with the first dose. Reversal equates to 1 successful use of sildenafil in each of 2 patients and 3 uses in 2 patients.
CONCLUSION: Sildenafil may be an effective treatment for serotonergic antidepressant-induced sexual dysfunction and deserves further evaluation in randomized placebo-controlled studies.
Volume
60
Issue
1
First Page
33
Last Page
35
ISSN
0160-6689
Published In/Presented At
Nurnberg, H. G., Lauriello, J., Hensley, P. L., Parker, L. M., & Keith, S. J. (1999). Sildenafil for iatrogenic serotonergic antidepressant medication-induced sexual dysfunction in 4 patients. The Journal of clinical psychiatry, 60(1), 33–35. https://doi.org/10.4088/jcp.v60n0107
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
10074875
Department(s)
Administration and Leadership
Document Type
Article