Slow wave sleep and computed tomographic measures of brain morphology in schizophrenia.
Publication/Presentation Date
3-29-1996
Abstract
To test the hypothesis that slow wave sleep in schizophrenia is inversely correlated with ventricular system volume, polysomnography and computed tomographic (CT) brain imaging were carried out in 14 psychiatric patients who met Research Diagnostic Criteria for schizophrenia (h = 11) or schizoaffective disorder (n = 3). Three measures of ventricular system volume were analyzed: (1) raw ventricular volume expressed in cm3; (2) ventricle-to-brain ratio; and (3) ventricular volume corrected for normal variation in age and head size expressed as a standardized (z) score. All three quantifications of ventricular volume were significantly and inversely correlated with visually scored measures of stage 3 and stage 4 sleep. This finding suggests that the etiology of slow wave sleep deficits in schizophrenia is related either directly or indirectly to underlying brain dysmorphology.
Volume
60
Issue
2-3
First Page
125
Last Page
134
ISSN
0165-1781
Published In/Presented At
Benson, K. L., Sullivan, E. V., Lim, K. O., Lauriello, J., Zarcone, V. P., Jr, & Pfefferbaum, A. (1996). Slow wave sleep and computed tomographic measures of brain morphology in schizophrenia. Psychiatry research, 60(2-3), 125–134. https://doi.org/10.1016/0165-1781(96)02705-9
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8723303
Department(s)
Administration and Leadership
Document Type
Article