Sirolimus-induced interstitial pneumonitis in a renal transplant patient.
Publication/Presentation Date
12-1-2005
Abstract
We report interstitial pneumonitis caused by sirolimus (Rapamune, an immunosuppressive agent) in a renal transplant patient. This rare manifestation was recently recognized as a troublesome adverse effect of sirolimus in many solid-organ transplant recipients, the majority of whom are kidney transplant recipients. While on sirolimus our patient developed cough, fever, and patchy infiltrates, which failed to respond to multiple courses of antibiotic therapy. Biopsy showed findings characteristic of drug-induced hypersensitivity pneumonitis, and excluded other entities, such as opportunistic infection. Improvement occurred only upon discontinuation of the sirolimus.
Volume
50
Issue
12
First Page
1659
Last Page
1661
ISSN
0020-1324
Published In/Presented At
Mingos, M. A., & Kane, G. C. (2005). Sirolimus-induced interstitial pneumonitis in a renal transplant patient. Respiratory care, 50(12), 1659–1661.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
16318648
Department(s)
Administration and Leadership
Document Type
Article