Retinal thickness analysis by race, gender, and age using Stratus OCT.
Publication/Presentation Date
3-1-2010
Abstract
PURPOSE: To detect differences in retinal thickness among patients of different race, gender, and age using Stratus OCT.
DESIGN: Cross-sectional study.
METHODS: In a multicenter, university-based study, 126 patients with no history of ocular disease were enrolled (78 diabetics without retinopathy and 48 nondiabetics). Optical coherence tomography measurements were performed using Stratus OCT. Statistical comparisons of center point foveal thickness and mean foveal thickness were made using generalized estimating equations adjusting for diabetic status, race, age, and gender.
RESULTS: The study population consisted of 36% male subjects, 39% Caucasian, 33% African-American, and 28% Hispanic. Mean foveal thickness was 191.6 +/- 2.7 microm and 194.5 +/- 2.7 microm for diabetics and nondiabetics, respectively (P = .49). Mean foveal thickness in male subjects was significantly larger than in female (201.8 +/- 2.7 microm and 186.9 +/- 2.6 microm, respectively; P < .001). Mean foveal thickness was 200.2 +/- 2.7 microm for Caucasian, 181.0 +/- 3.7 microm for African-American, and 194.7 +/- 3.9 microm for Hispanic subjects. Mean foveal thickness was significantly less for African-American than Caucasian (P < .0001) or Hispanic subjects (P = .005). Center point foveal thickness and mean foveal thickness showed a significant increase with age.
CONCLUSIONS: There are statistically significant differences in retinal thickness between subjects of different race, gender, and age. When compared to Caucasian and Hispanic subjects, African-American race is a predictor of decreased mean foveal thickness; and male sex (regardless of race) is a significant predictor of increased mean foveal thickness. Mean foveal thickness is similar among diabetics and nondiabetics when data are controlled for age, race, and sex. These results suggest that studies comparing OCT measurements should carefully control for age-based, race-based, and gender-based variations in retinal thickness.
Volume
149
Issue
3
First Page
496
Last Page
502
ISSN
1879-1891
Published In/Presented At
Kashani, A. H., Zimmer-Galler, I. E., Shah, S. M., Dustin, L., Do, D. V., Eliott, D., Haller, J. A., & Nguyen, Q. D. (2010). Retinal thickness analysis by race, gender, and age using Stratus OCT. American journal of ophthalmology, 149(3), 496–502.e1. https://doi.org/10.1016/j.ajo.2009.09.025
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
20042179
Document Type
Article