Correlation of visual acuity and macular thickness measured by optical coherence tomography in patients with persistent macular edema.

Authors

• Mark S Blumenkranz
• Julia A Haller
• Baruch D Kuppermann
• George A Williams
• Michael Ip
• Matthew Davis
• David V Weinberg
• Connie Chou
• Scott M Whitcup

Publication/Presentation Date

1-1-2010

Abstract

PURPOSE: The purpose of this study was to evaluate the correlation between best-corrected visual acuity (BCVA) and macular thickness in patients with persistent macular edema treated with a dexamethasone intravitreal drug delivery system (dexamethasone DDS).

METHODS: In a randomized, multicenter, controlled, parallel-group, dose-ranging study, patients with macular edema lasting at least 90 days despite treatment were randomized to observation or treatment with 350- or 700-microg dexamethasone DDS. Macular thickness was assessed in 80 patients using optical coherence tomography. Best-corrected visual acuity was measured using Early Treatment Diabetic Retinopathy Study methodology.

RESULTS: At baseline, macular thickness was significantly inversely correlated with BCVA (r = -0.406, P < 0.001). Patients treated with 350- or 700-microg dexamethasone DDS showed a significant decrease in macular thickness from baseline to Day 90 (P = 0.002). In the 700-microg dexamethasone DDS treatment group, there was a modest inverse correlation between changes in macular thickness from baseline to Day 90 and improvement in BCVA (r = -0.530, P = 0.009). In the 350-microg dexamethasone DDS treatment group, the correlation was weaker and not statistically significant (r = -0.206, P = 0.304).

CONCLUSION: The correlation between baseline BCVA and macular thickness in patients with persistent macular edema was modest. Improvement in BCVA after treatment with 700-microg dexamethasone DDS was consistent with changes in macular thickness measured using optical coherence tomography.

Volume

30

Issue

7

First Page

1090

Last Page

1094

ISSN

1539-2864

Published In/Presented At

Blumenkranz, M. S., Haller, J. A., Kuppermann, B. D., Williams, G. A., Ip, M., Davis, M., Weinberg, D. V., Chou, C., & Whitcup, S. M. (2010). Correlation of visual acuity and macular thickness measured by optical coherence tomography in patients with persistent macular edema. Retina (Philadelphia, Pa.), 30(7), 1090–1094. https://doi.org/10.1097/IAE.0b013e3181dcfaf3

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

20616686

Department(s)

Administration and Leadership

Document Type

Article