Oct-based interpretation of the vitreomacular interface and indications for pharmacologic vitreolysis.

Authors

• Peter Stalmans
• Jay S Duker
• Peter K Kaiser
• Jeffrey S Heier
• Pravin U Dugel
• Arnd Gandorfer
• J Sebag
• Julia A Haller

Publication/Presentation Date

1-1-2013

Abstract

PURPOSE: To review the role of optical coherence tomography (OCT) in diagnosis and management of vitreomacular disease and the impact of OCT on potential uses of ocriplasmin, a new pharmacologic vitreolysis agent recently approved by the U.S. Food and Drug Administration for the treatment of symptomatic vitreomacular adhesion.

METHODS: Analysis of current literature regarding OCT in diagnosis and management of vitreomacular interface disease.

RESULTS: Posterior vitreous detachment is typically a nonpathologic age-related event. Anomalous posterior vitreous detachment emerges when the vitreous cortex fails to cleanly detach from the macula, optic nerve, or other adherent sites. Focal vitreomacular adhesion is a nonpathologic anatomical designation associated with perifoveal posterior vitreous detachment but normal retinal morphology on OCT. Vitreomacular traction is a pathologic consequence of persistent vitreous attachment with structural disturbance of the macular retina visible on OCT. Full-thickness macular holes are foveal defects continuous through all retinal layers to the retinal pigment epithelium. Vitreomacular traction and macular hole with focal vitreomacular adhesion are indications for pharmacologic vitreolysis.

CONCLUSION: Noninvasive high-resolution OCT imaging has transformed the understanding of vitreomacular interface disease. Careful evaluation of the vitreomacular interface with OCT has increased in importance with the introduction of ocriplasmin for vitreomacular adhesion associated with symptomatic anatomical retinal changes.

Volume

33

Issue

10

First Page

2003

Last Page

2011

ISSN

1539-2864

Published In/Presented At

Stalmans, P., Duker, J. S., Kaiser, P. K., Heier, J. S., Dugel, P. U., Gandorfer, A., Sebag, J., & Haller, J. A. (2013). Oct-based interpretation of the vitreomacular interface and indications for pharmacologic vitreolysis. Retina (Philadelphia, Pa.), 33(10), 2003–2011. https://doi.org/10.1097/IAE.0b013e3182993ef8

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

23881226

Department(s)

Administration and Leadership

Document Type

Article