Use of multi-modal non-contrast MRI to predict functional outcomes after stroke: A study using DP-pCASL, DTI, NODDI, and MAP MRI.
Publication/Presentation Date
1-1-2025
Abstract
PURPOSE: This study aims to assess whether water exchange rate (k
METHODS: We studied 22 AIS patients enrolled from 1/2022 to 4/2024 who underwent multi-modal non-contrast imaging on a 3.0-Tesla scanner, including DP-pCASL, DTI, NODDI and MAP imaging. For each parametric map, the intensity and standard deviation (SD) were calculated for the infarcted region. The diffusion maps included were b0, Fractional Anisotropy (FA), Mean Diffusivity (MD), Intra-cellular Volume Fraction (ICVF), Free Water Fraction (FWF), and Orientation Dispersion Index (ODI), q-Space Mean Square Displacement (QMSD), Return-to-Axis Probability (RTAP), Return-to-Plane Probability (RTPP), Return-to-Origin Probability (RTOP), Propagator Anisotropy (PA), and non-Gaussianity (NG). The perfusion-based maps were cerebral blood flow (CBF), arterial transit time (ATT), and k
RESULTS: Twenty-two patients were included. The average age was 69.5 ± 13.5, the mean NIHSS of 12.4 ± 7.7, and the median infarct of 25.7 (8.4-98.8) ml. Multivariable linear regression identified lower k
CONCLUSIONS: Lower k
Volume
45
First Page
103742
Last Page
103742
ISSN
2213-1582
Published In/Presented At
Diamandi, J., Raimondo, C., Piper, K., Roy, J., Serva, S., Alizadeh, M., Flanders, A., Tjoumakaris, S., Gooch, R., Jabbour, P., Rosenwasser, R., & Mouchtouris, N. (2025). Use of multi-modal non-contrast MRI to predict functional outcomes after stroke: A study using DP-pCASL, DTI, NODDI, and MAP MRI. NeuroImage. Clinical, 45, 103742. https://doi.org/10.1016/j.nicl.2025.103742
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
39864167
Department(s)
Administration and Leadership
Document Type
Article