Does hormonal therapy influence sexual function in men receiving 3D conformal radiation therapy for prostate cancer?
Publication/Presentation Date
7-1-2001
Abstract
PURPOSE: We evaluated the effect of three-dimensional conformal radiation therapy (3D-CRT) with or without hormonal therapy (HT) on sexual function (SF) in prostate cancer patients whose SF was known before all treatment.
METHODS AND MATERIALS: Between March 1996 and March 1999, 144 patients received 3D-CRT (median dose = 70.2 Gy, range 66.6-79.2 Gy) for prostate cancer and had pre- and post-therapy SF data. All SF data were obtained with the O'Leary Brief SF Inventory, a self-administered, multidimensional, validated instrument. We defined total sexual potency as erections firm enough for penetration during intercourse. Mean follow-up time was 21 months (SD +/- 11 months). The Wilcoxon signed-rank test was used to test for significance of the change from baseline.
RESULTS: Before 3D-CRT, 87 (60%) of 144 men were totally potent as compared to only 47 (47%) of 101 at 1-year follow-up. Of the 60 men totally potent at baseline and followed for at least 1 year, 35 (58%) remained totally potent. These changes corresponded to a significant reduction in SF (p < 0.05). Patients who had 3D-CRT alone were more likely to be totally potent at 1 year than those receiving 3D-CRT with HT (56% vs. 31%, p = 0.012); however, they were also more likely to be potent at baseline (71% vs. 44%, p = 0.001). Although these two groups had a significant reduction in SF from baseline, their change was not significantly different from each other.
CONCLUSION: These data indicate that 3D-CRT causes a significant reduction in total sexual potency as compared to pretreatment baseline. The addition of HT does not appear to increase the risk of sexual dysfunction.
Volume
50
Issue
3
First Page
591
Last Page
595
ISSN
0360-3016
Published In/Presented At
Chen, C. T., Valicenti, R. K., Lu, J., Derose, T., Dicker, A. P., Strup, S. E., Mulholland, S. G., Hirsch, I. H., McGinnis, D. E., & Gomella, L. G. (2001). Does hormonal therapy influence sexual function in men receiving 3D conformal radiation therapy for prostate cancer?. International journal of radiation oncology, biology, physics, 50(3), 591–595. https://doi.org/10.1016/s0360-3016(01)01504-8
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11395224
Department(s)
Administration and Leadership
Document Type
Article