Defining a future role for radiogenic therapy.
Publication/Presentation Date
10-1-2001
Abstract
The goal of cancer therapy is to eliminate the cancer and/or to arrest further growth while decreasing normal tissue toxicity, i.e. to increase the therapeutic ratio. This review focuses on a group of therapeutics that are either (1) directly stimulated by radiation to produce either directly or indirectly cytotoxic agents (i.e. genes under the control of a radiation inducible promoter that produce a cytotoxic protein or an enzyme that converts a prodrug to an active form, respectively); (2) auger-electron emitting radiolabelled oligonucleotides, antibodies, nucleotide analogues, or other small molecules that are internalized; (3) radiation inducible genes that produce a ligand or transporter (or the like) which then can be targeted by cytotoxic agents (e.g. radiolabelled substance). We have termed this group of therapeutics radiogenic therapy.
Volume
27
Issue
5
First Page
289
Last Page
294
ISSN
0305-7372
Published In/Presented At
Kaminski, J. M., Kaminski, R. J., Dicker, A. P., & Urbain, J. L. (2001). Defining a future role for radiogenic therapy. Cancer treatment reviews, 27(5), 289–294. https://doi.org/10.1053/ctrv.2001.0236
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11871865
Department(s)
Administration and Leadership
Document Type
Article