The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments.
Publication/Presentation Date
8-1-2011
Abstract
The CDKN2A gene is a tumor suppressor that encodes the CDK4/6 inhibitor p16(ink4a). Loss of this tumor suppressor contributes to the bypass of critical senescent signals and is associated with progression to malignant disease. However, the high-level expression of p16(ink4a) in tumors is associated with aggressive subtypes of disease, and in certain clinical settings elevated p16(ink4a) expression is an important determinant for disease prognosis and therapeutic response. These seemingly contradictory facets of p16(ink4a) expression have lead to confusion related to the meaning of this tumor suppression in tumor pathobiology. As reviewed here, the alternative expression of p16(ink4a) represents an ideal marker for considering RB-pathway function, tumor heterogeneity, and novel means for directing therapy.
Volume
10
Issue
15
First Page
2497
Last Page
2503
ISSN
1551-4005
Published In/Presented At
Witkiewicz, A. K., Knudsen, K. E., Dicker, A. P., & Knudsen, E. S. (2011). The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments. Cell cycle (Georgetown, Tex.), 10(15), 2497–2503. https://doi.org/10.4161/cc.10.15.16776
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21775818
Department(s)
Administration and Leadership
Document Type
Article