Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma.
Publication/Presentation Date
5-30-2010
Abstract
PURPOSE: This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression.
METHODS: Following institutional review board approval, 113 meningioma specimens from 89 patients were chosen. Of these, 85 were used for final analysis. After a blinded review, immunohistochemical stains for EGFR were performed. Staining intensity (SI) was scored on a scale 0-3 (from no staining to strong staining). Staining percentage of immunoreactive cells (SP) was scored 1-5 (from the least to the maximum percent of the specimen staining). Immunohistochemical score (IHS) was calculated as the product of SI and SP.
RESULTS: Eighty-five samples of meningioma were classified in accordance with World Health Organization (WHO) criteria: benign 57/85 (67%), atypical 23/85 (27%), and malignant 5/85 (6%). The majority of samples demonstrated a moderate SI for EGFR. IHS for EGFR demonstrated a significant association between SI and histopathologic subtype. Also, there was a correlation between the SP and histopathologic subtype (p = 0.029). A significant association was determined when the benign and the atypical samples were compared to the malignant with respect to the SP (p = 0.009). While there was a range of the IHS for the benign and the atypical histologic subtypes, malignant tumors exhibited the lowest score and were statistically different from the benign and the atypical specimens (p < 0.001).
CONCLUSIONS: To our knowledge, this represents the largest series of meningioma samples analyzed for EGFR expression reported in the literature. EGFR expression is greatest in benign meningiomas and may serve a potential target for therapeutic intervention with selective EGFR inhibitors.
Volume
5
First Page
46
Last Page
46
ISSN
1748-717X
Published In/Presented At
Wernicke, A. G., Dicker, A. P., Whiton, M., Ivanidze, J., Hyslop, T., Hammond, E. H., Perry, A., Andrews, D. W., & Kenyon, L. (2010). Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma. Radiation oncology (London, England), 5, 46. https://doi.org/10.1186/1748-717X-5-46
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
20509969
Department(s)
Administration and Leadership
Document Type
Article