Zebrafish: an emerging model system for human disease and drug discovery.
Publication/Presentation Date
7-1-2007
Abstract
In vivo studies represent an essential step in drug development and currently rely largely on mice, yet limitations of mammalian models motivated the search for complementary vertebrate model systems. This review focuses on zebrafish, Danio rerio, as a facile model system to study human disease and drug responses. Zebrafish are particularly suited for this purpose because they represent a vertebrate species, their genome is sequenced, and a large number of synchronously developing, transparent embryos can be produced. Zebrafish embryos are permeable to drugs and can easily be manipulated using well-established genetic and molecular approaches. Here, we summarize recent work on drug discovery and toxicity in zebrafish embryos. In addition, we provide a synopsis of current efforts to establish disease models in zebrafish focusing on neoplasia. The results of these studies highlight the potential of zebrafish as a viable addition to established animal models by offering medium and, potentially, high throughput capabilities.
Volume
82
Issue
1
First Page
70
Last Page
80
ISSN
0009-9236
Published In/Presented At
Kari, G., Rodeck, U., & Dicker, A. P. (2007). Zebrafish: an emerging model system for human disease and drug discovery. Clinical pharmacology and therapeutics, 82(1), 70–80. https://doi.org/10.1038/sj.clpt.6100223
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
17495877
Department(s)
Administration and Leadership
Document Type
Article