Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade.
Publication/Presentation Date
1-1-2005
Abstract
Antiandrogen therapy is an important modality in the treatment of prostate cancer. Recent research into the role of angiogenesis in tumour growth and metastasis has uncovered links between antiandrogen therapy, radiation therapy and angiogenesis, which have exciting implications for the treatment of prostate cancer. Angiogenic cytokines such as vascular endothelial growth factor (VEGF) have been identified in prostate cancer cells and tumours, and androgens appear to stimulate VEGF. This article assesses the antiangiogenic effects of hormonal therapy and assesses the role that angiogenesis may play in the observed cooperation between hormonal and radiation therapies for prostate cancer.
Volume
8
Issue
2
First Page
127
Last Page
132
ISSN
1365-7852
Published In/Presented At
Woodward, W. A., Wachsberger, P., Burd, R., & Dicker, A. P. (2005). Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade. Prostate cancer and prostatic diseases, 8(2), 127–132. https://doi.org/10.1038/sj.pcan.4500779
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
15643450
Department(s)
Administration and Leadership
Document Type
Article