Nutrient restriction and radiation therapy for cancer treatment: when less is more.
Publication/Presentation Date
1-1-2013
Abstract
Calorie restriction (CR), or a diet modification aiming to reduce the total intake of calories by 20%-40%, has been shown to increase longevity across multiple species. Recently, there has been growing interest in investigating the potential role of CR as a treatment intervention for age-related diseases, such as cancer, because an increasing body of literature has demonstrated a metabolic component to both carcinogenesis and tumor progression. In fact, many of the molecular pathways that are altered with CR are also known to be altered in cancer. Therefore, manipulation of these pathways using CR can render cancer cells, and most notably breast cancer cells, more susceptible to standard cytotoxic treatment with radiation and chemotherapy. In this review article we demonstrate the laboratory and clinical evidence that exists for CR and show compelling evidence through the molecular pathways CR induces about how it may be used as a treatment in tandem with radiation therapy to improve our rates of disease control.
Volume
18
Issue
1
First Page
97
Last Page
103
ISSN
1549-490X
Published In/Presented At
Champ, C. E., Baserga, R., Mishra, M. V., Jin, L., Sotgia, F., Lisanti, M. P., Pestell, R. G., Dicker, A. P., & Simone, N. L. (2013). Nutrient restriction and radiation therapy for cancer treatment: when less is more. The oncologist, 18(1), 97–103. https://doi.org/10.1634/theoncologist.2012-0164
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23299773
Department(s)
Administration and Leadership
Document Type
Article