Systematic review of hypofractionated radiation therapy for prostate cancer.
Publication/Presentation Date
11-1-2013
Abstract
Prostate cancer is the second most prevalent solid tumor diagnosed in men in the United States and Western Europe. Conventionally fractionated external beam radiation therapy (1.8-2.0 Gy/fraction) is an established treatment modality for men in all disease risk groups. Emerging evidence from experimental and clinical studies suggests that the α/β ratio for prostate cancer may be as low as 1.5 Gy, which has prompted investigators around the world to explore moderately hypofractionated radiation therapy (2.1-3.5 Gy/fraction). We review the impetus behind moderate hypofractionation and the current clinical evidence supporting moderate hypofractionated radiation therapy for prostate cancer. Although hypofractionated radiation therapy has many theoretical advantages, there is no clear evidence from prospective, randomized, controlled trials showing that hypofractionated schedules have improved outcomes or lower toxicity than conventionally fractionated regimens. Currently, hypofractionated schedules should only be used in the context of clinical trials. High dose rate brachytherapy and stereotactic body radiation therapy (fraction size 3.5 Gy and greater) are alternative approaches to hypofractionation, but are beyond the scope of this report.
Volume
39
Issue
7
First Page
728
Last Page
736
ISSN
1532-1967
Published In/Presented At
Zaorsky, N. G., Ohri, N., Showalter, T. N., Dicker, A. P., & Den, R. B. (2013). Systematic review of hypofractionated radiation therapy for prostate cancer. Cancer treatment reviews, 39(7), 728–736. https://doi.org/10.1016/j.ctrv.2013.01.008
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23453861
Department(s)
Administration and Leadership
Document Type
Article