A paradigm shift from anatomic to functional and molecular imaging in the detection of recurrent prostate cancer.
Publication/Presentation Date
2-1-2014
Abstract
Approximately a third of men with localized prostate cancer who are treated with external beam radiation therapy (EBRT) or radical prostatectomy (RP) develop biochemical failure (BF). Presumably, BF will progress to distant metastasis and prostate cancer-specific mortality in some patients over subsequent years. Accurate detection of recurrent disease is important because it allows for appropriate treatment selection (e.g., local vs systemic therapy) and early delivery of therapy (e.g., salvage EBRT), which affect patient outcome. In this article, we discuss the paradigm shift in imaging technology in the detection of recurrent prostate cancer. First, we discuss the commonly used morphological and anatomical imaging modalities and their role in the post-RP and post-EBRT settings of BF. Second, we discuss the accuracy of functional and molecular imaging techniques, many of which are under investigation. Further studies are needed to establish the role of imaging techniques for detection of cancer recurrence and clinical decision-making.
Volume
10
Issue
3
First Page
457
Last Page
474
ISSN
1744-8301
Published In/Presented At
Zaorsky, N. G., Yamoah, K., Thakur, M. L., Trabulsi, E. J., Showalter, T. N., Hurwitz, M. D., Dicker, A. P., & Den, R. B. (2014). A paradigm shift from anatomic to functional and molecular imaging in the detection of recurrent prostate cancer. Future oncology (London, England), 10(3), 457–474. https://doi.org/10.2217/fon.13.196
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
24559451
Department(s)
Administration and Leadership
Document Type
Article