The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules.
Publication/Presentation Date
1-1-2018
Abstract
In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the interactions of tumor cells with their microenvironment. Recent technological advances in planning and delivery of external beam radiotherapy have allowed delivery of larger doses per fraction (hypofractionation) while minimizing dose to normal tissues with higher precision. The effects of radiation on the tumor microenvironment vary with dose and fractionation schedule. In this review, we summarize the effects of conventional and hypofractionated radiation regimens on the immune system and tumor stroma. We discuss how these interactions may provide therapeutic benefit in combination with targeted therapies. Understanding the differential effects of radiation dose and fractionation can have implications for choice of combination therapies.
Volume
11
First Page
1179064418761639
Last Page
1179064418761639
ISSN
1179-0644
Published In/Presented At
Arnold, K. M., Flynn, N. J., Raben, A., Romak, L., Yu, Y., Dicker, A. P., Mourtada, F., & Sims-Mourtada, J. (2018). The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules. Cancer growth and metastasis, 11, 1179064418761639. https://doi.org/10.1177/1179064418761639
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
29551910
Department(s)
Administration and Leadership
Document Type
Article