Prospective Trial of Functional Lung Avoidance Radiation Therapy for Lung Cancer: Quality of Life Report.

Authors

• Joseph Lombardo
• Edward Castillo
• Richard Castillo
• Ryan Miller
• Bernard Jones
• Moyed Miften
• Brian Kavanagh
• Adam Dicker
• Cullen Boyle
• Benjamin Leiby
• Joshua Banks
• Nicole L Simone
• Benjamin Movsas
• Inga Grills
• Thomas Guerrero
• Chad G Rusthoven
• Yevgeniy Vinogradskiy

Publication/Presentation Date

10-1-2024

Abstract

PURPOSE: A novel form of lung function imaging has been developed that uses 4-dimensional computed tomography (4DCT) data to generate lung ventilation images (4DCT-ventilation). Functional avoidance uses 4DCT-ventilation to reduce doses to functional lung with the aim of reducing pulmonary side effects. A phase 2, multicenter 4DCT-ventilation functional avoidance clinical trial was completed. The purpose of this work was to quantify changes in patient-reported outcomes (PROs) for patients treated with functional avoidance and determine which metrics are predictive of PRO changes.

MATERIALS AND METHODS: Patients with locally advanced lung cancer receiving curative-intent radiation therapy were accrued. Each patient had a 4DCT-ventilation image generated using 4DCT data and image processing. PRO instruments included the Functional Assessment of Cancer Therapy-Lung (FACT-L) questionnaire administered pretreatment; at the end of treatment; and at 3, 6, and 12 months posttreatment. Using the FACT-Trial Outcome Index and the FACT-Lung Cancer Subscale results, the percentage of clinically meaningful declines (CMDs) were determined. A linear mixed-effects model was used to determine which patient, clinical, dose, and dose-function metrics were predictive of PRO decline.

RESULTS: Of the 59 patients who completed baseline PRO surveys. 83% had non-small cell lung cancer, with 75% having stage 3 disease. The median dose was 60 Gy in 30 fractions. CMD FACT-Trial Outcome Index decline was 46.3%, 38.5%, and 26.8%, at 3, 6, and 12 months, respectively. CMD FACT-Lung Cancer Subscale decline was 33.3%, 33.3%, and 29.3%, at 3, 6, and 12 months, respectively. Although an increase in most dose and dose-function parameters was associated with a modest decline in PROs, none of the results were significant (all P > .053).

CONCLUSIONS: The current work presents an innovative combination of use of functional avoidance and PRO assessment and is the first report of PROs for patients treated with prospective 4DCT-ventilation functional avoidance. Approximately 30% of patients had clinically significant decline in PROs at 12 months posttreatment. The study provides additional data on outcomes with 4DCT-ventilation functional avoidance.

Volume

120

Issue

2

First Page

593

Last Page

602

ISSN

1879-355X

Published In/Presented At

Lombardo, J., Castillo, E., Castillo, R., Miller, R., Jones, B., Miften, M., Kavanagh, B., Dicker, A., Boyle, C., Leiby, B., Banks, J., Simone, N. L., Movsas, B., Grills, I., Guerrero, T., Rusthoven, C. G., & Vinogradskiy, Y. (2024). Prospective Trial of Functional Lung Avoidance Radiation Therapy for Lung Cancer: Quality of Life Report. International journal of radiation oncology, biology, physics, 120(2), 593–602. https://doi.org/10.1016/j.ijrobp.2024.03.046

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

38614278

Department(s)

Administration and Leadership

Document Type

Article