Predictors of Mortality in HPV-Associated Oropharynx Carcinoma Treated With Surgery Alone.
Publication/Presentation Date
7-1-2020
Abstract
OBJECTIVE: Survival outcomes for human papillomavirus-associated oropharynx squamous cell carcinoma (HPV + OPSCC) treated with surgery alone are unclear. To increase understanding, we assessed overall survival (OS) outcomes using the national cancer database (NCDB).
METHODS: We conducted a retrospective analysis of OS of 736 NCDB HPV + OPSCC patients who underwent surgery alone from 2010 to 2014 using univariate and multivariate analyses and the Kaplan-Meir method.
RESULTS: Multivariable analysis found the following independent risk factors for death: American Joint Commission on Cancer (AJCC) 8th edition pathologic stage(p)N2 versus pN0 disease (hazard ratio [HR], 5.5; P = 0.000006), macroscopic extranodal extension (ENE) versus non-ENE (HR, 4.9; P < 0.02), a positive lymph nodes (LN) percentage of ≥10% (HR, 4.2; P = 0.0002), and five or more positive LNs (HR, 4.9; P = 0.00004). Three-year OS was significantly worse for AJCC 8th edition pN2 versus pN0 but not for 7th edition pN2 versus pN0 disease. Five-year OS was significantly worse for positive versus negative surgical margins, AJCC 8th edition stage II versus I, and either microscopic or macroscopic ENE versus non-ENE positive LNs. For 523 (71%) AJCC 8th edition stage I patients and for 283 (38%) patients who were pT1-T2, with negative margins, pN0-N1, with ≤4 pathologic LNs, without ENE, and with >20 LNs removed during neck dissection, the 3-year OS rates were 93% and 95%, respectively, and the 5-year OS rates were 91% and 95%, respectively.
CONCLUSION: In the context of the lack of detail and possible inaccuracies found in the NCDB, surgery alone for AJCC 8th edition stage I HPV + OPSCC, particularly pT1-T2, pN0-N1 with ≤4 pathologic LNs, without ENE, and with negative surgical margins has a high OS.
LEVEL OF EVIDENCE: 4 Laryngoscope, 130:E423-E435, 2020.
Volume
130
Issue
7
First Page
423
Last Page
423
ISSN
1531-4995
Published In/Presented At
Han, M., Stanford-Moore, G. B., Larson, A. R., Schoppy, D. W., Cognetti, D. M., Joshi, A. S., Houlton, J. J., & Ryan, W. R. (2020). Predictors of Mortality in HPV-Associated Oropharynx Carcinoma Treated With Surgery Alone. The Laryngoscope, 130(7), E423–E435. https://doi.org/10.1002/lary.28344
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
31675132
Department(s)
Administration and Leadership
Document Type
Article