Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya.
Publication/Presentation Date
6-1-2013
Abstract
The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase-polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1β that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.
Volume
63
Issue
2
First Page
245
Last Page
248
ISSN
1944-7884
Published In/Presented At
Coleman, J. S., Mwachari, C., Balkus, J., Sanguli, L., Muliro, A., Agnew, K., Coombs, R. W., Cohen, C. R., & Hitti, J. (2013). Effect of the levonorgestrel intrauterine device on genital HIV-1 RNA shedding among HIV-1-infected women not taking antiretroviral therapy in Nairobi, Kenya. Journal of acquired immune deficiency syndromes (1999), 63(2), 245–248. https://doi.org/10.1097/QAI.0b013e31828decf8
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23446496
Department(s)
Administration and Leadership
Document Type
Article