Pilot study of fractional CO
Publication/Presentation Date
2-1-2021
Abstract
PURPOSE: The objectives of this study were to evaluate the feasibility and efficacy of fractional CO
METHODS: This was a pilot, multi-institutional randomized sham-controlled trial of women with gynecologic cancers with dyspareunia and/or vaginal dryness. Participants were randomized to fractional CO
RESULTS: Eighteen women participated in the study, ten in the treatment arm and eight in the sham arm. The majority of participants had stage I (n = 11, 61.1 %) or II (n = 3, 16.7 %) endometrial cancer with adenocarcinoma histology (n = 9, 50 %). In total, 15 (83.3 %) of the participants completed all treatments and follow-up visit. There was no difference in the change in the median VAS score from baseline to follow-up. However, there was an improvement in change in the median total FSFI score with treatment compared with sham (Δ 6.5 vs -0.3, p = 0.02). The change in the median UDI-6 score was lower in the treatment arm (Δ -14.6 vs -2.1, p = 0.17), but this was not statistically significant. There were no reported serious adverse events.
CONCLUSIONS: Fractional CO
Volume
144
First Page
37
Last Page
44
ISSN
1873-4111
Published In/Presented At
Quick, A. M., Dockter, T., Le-Rademacher, J., Salani, R., Hudson, C., Hundley, A., Terstriep, S., Streicher, L., Faubion, S., Loprinzi, C. L., Coleman, J. S., Wang, K. C., & Lustberg, M. (2021). Pilot study of fractional CO2 laser therapy for genitourinary syndrome of menopause in gynecologic cancer survivors. Maturitas, 144, 37–44. https://doi.org/10.1016/j.maturitas.2020.10.018
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33358206
Department(s)
Administration and Leadership
Document Type
Article