Maternal and Fetal Outcomes in an Observational Cohort of Women With Mycoplasma genitalium Infections.
Publication/Presentation Date
12-1-2021
Abstract
BACKGROUND: Despite evidence that Mycoplasma genitalium (MG) is a risk factor for adverse outcomes in pregnancy, screening in pregnant women is not currently recommended.
METHODS: Pregnant women between the ages of 13 and 29 years were recruited during their routine prenatal visits, screened for sexually transmitted infections (STIs) and followed for 1 year. We compared women with MG to those with no STIs, excluding women with STIs other than MG (Chlamydia trachomatis [CT], Neisseria gonorrhoeae [NG], or Trichomonas vaginalis [TV]) unless they were also codiagnosed with MG. Adverse outcomes were extracted from participants' medical records and compared between women with MG and those without STIs using exact or nonparametric approaches. Estimated differences were also adjusted for demographics using propensity scores with linear and logistic regression, where appropriate. We exclude women with MG and CT, NG, or TV diagnosis for primary analysis.
RESULTS: Of 281 participants enrolled from September 2015 until July 2019, 51 (18.1%) were diagnosed with MG. Of 51 women with MG, 12 (24%) were also diagnosed with CT, NG, or TV. All women with MG were offered treatment with azithromycin; however, only 28 (55%) were documented to receive treatment. Women with MG had similar outcomes to those with no STIs with a few exceptions. Average birth weight was lower among women with MG alone compared with women with no STIs when excluding coinfections (169-g difference, 15-323).
CONCLUSIONS: Our results indicate that MG is common in pregnant women and often presents as a coinfection. More research using population-based designs is needed to determine whether screening or treatment for women at risk for low birth weight or coinfections is warranted.
Volume
48
Issue
12
First Page
991
Last Page
996
ISSN
1537-4521
Published In/Presented At
Perin, J., Coleman, J. S., Ronda, J., Neibaur, E., Gaydos, C. A., & Trent, M. (2021). Maternal and Fetal Outcomes in an Observational Cohort of Women With Mycoplasma genitalium Infections. Sexually transmitted diseases, 48(12), 991–996. https://doi.org/10.1097/OLQ.0000000000001569
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34654767
Department(s)
Administration and Leadership
Document Type
Article