A scoping review of penile implant biofilms-what do we know and what remains unknown?
Publication/Presentation Date
8-1-2022
Abstract
BACKGROUND: Penile prosthesis (PP) is a gold standard for treatment of erectile dysfunction given its reliability and efficacy. Infection remains the most feared complication of prosthetic surgery, which usually results in device removal, and places a significant economic burden on the healthcare system. While biofilms have shown to support the persistence of microorganisms, the degree by which this matrix is truly pathogenic remains unknown given its high prevalence even in asymptomatic patients. We aim to review and summarize the current literature pertaining to biofilm formation in the setting of PP surgeries in clinically infected and non-infected cases.
METHODS: Searches were performed in the MEDLINE online database through PubMed using a combination of keywords "penile prosthetic" OR "penile prosthesis" OR "penile implant" AND "biofilm" OR "revision" OR "removal" OR "infection" OR "explant". Eleven articles met inclusion criteria. There were only three studies that explicitly listed the number of biofilms identified in their cohort, but we also included eight articles that mentioned swabbing and culturing of any bacterial biofilm during revision procedures for both clinically infected and non-infected implants.
RESULTS: Infected PP yielded a 11-100% rate of biofilm presence, while non-infected PP yielded a 3-70% rate of biofilm presence. Time to reoperation from initial PP placement were also largely variable, ranging from 2 weeks to over 2 years. Coagulase-negative staphylococcus (i.e.,
CONCLUSIONS: Since the advent of PP surgery, diabetes control, revision washout protocols and antibiotic-impregnated devices have led to an overall decrease in biofilm formation and infectious complications. There is an overall paradigm shift in microbial profiles with more virulent organisms, such as
Volume
11
Issue
8
First Page
1210
Last Page
1221
ISSN
2223-4691
Published In/Presented At
Leong, J. Y., Capella, C. E., D'Amico, M. J., Isguven, S., Purtill, C., Machado, P., Delaney, L. J., Henry, G. D., Hickok, N. J., Forsberg, F., & Chung, P. H. (2022). A scoping review of penile implant biofilms-what do we know and what remains unknown?. Translational andrology and urology, 11(8), 1210–1221. https://doi.org/10.21037/tau-22-195
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
36092843
Department(s)
Administration and Leadership
Document Type
Article