Hydrophilic inflatable penile prosthesis surface coatings readily rebind antibiotics and maintain antimicrobial efficacy ex vivo.

Authors

• Brian H Im
• Aaron R Hochberg
• Analyse H Giordano
• Rachel Evans
• Andrzej Fertala
• Jolanta Fertala
• Noreen J Hickok
• Paul H Chung

Publication/Presentation Date

2-1-2026

Abstract

Hydrophilic penile prosthesis (PP) surfaces removed during revision surgery may potentially rebind antiseptics and maintain antimicrobial efficacy ex vivo. Coloplast Titan reservoirs and cylinders were retrieved during revision surgery for mechanical failure. Congo Red staining and contact angle measurements were performed to evaluate the integrity of the hydrophilic surface. Fluorescent antibiotic binding was performed by submerging discs for 3 min in either fluorescein-isothiocyanate (FITC) labeled or unlabeled vancomycin at 2 mg/mL. Fluorescence was quantified via ImageJ. 8 mm discs were submerged for 3 min in normal saline (NS), 0.05% chlorhexidine gluconate, or a 2 mg/mL vancomycin and 160 μg/mL gentamicin (VG) antibiotic, then incubated with 10

Volume

38

Issue

2

First Page

134

Last Page

140

ISSN

1476-5489

Published In/Presented At

Im, B. H., Hochberg, A. R., Giordano, A. H., Evans, R., Fertala, A., Fertala, J., Hickok, N. J., & Chung, P. H. (2026). Hydrophilic inflatable penile prosthesis surface coatings readily rebind antibiotics and maintain antimicrobial efficacy ex vivo. International journal of impotence research, 38(2), 134–140. https://doi.org/10.1038/s41443-025-01104-8

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

40500460

Department(s)

Administration and Leadership

Document Type

Article