Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.
Publication/Presentation Date
3-1-1993
Abstract
We have investigated three prostatic cancer cell lines, PC-3, DU-145, and LNCa.FGC, and found that all three cell lines can grow in serum-free medium without the addition of exogenous growth factors. All three cell lines produce substantial amounts of insulin-like growth factor 1 (IGF-1) that is secreted in the medium and they all display constitutively autophosphorylated IGF-1 receptors; two of the cell lines overexpress IGF-1 receptor RNA. The growth of all three cell lines is inhibited by an antisense oligodeoxynucleotide to IGF-1 receptor RNA or by peptide analogues of IGF-1 that compete with IGF-1 binding to its receptor. Our results indicate that these three cell lines grow by an autocrine loop in which the overproduced IGF-1 activates its receptor. Interference with the activation of the receptor leads to cessation of growth.
Volume
53
Issue
5
First Page
1102
Last Page
1106
ISSN
0008-5472
Published In/Presented At
Pietrzkowski, Z., Mulholland, G., Gomella, L., Jameson, B. A., Wernicke, D., & Baserga, R. (1993). Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1. Cancer research, 53(5), 1102–1106.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8439954
Department(s)
Administration and Leadership
Document Type
Article