Molecular genetics of prostate cancer: clinical translational opportunities.
Publication/Presentation Date
3-1-2007
Abstract
Prostate cancer (PC) development reflects a complex sequence of biologic and molecular events. Several inheritable and somatic genetic changes have been identified. The knowledge of the molecular basis of PC can improve our understanding of the causes of this common cancer and provide information on prognosis and treatment. To date, however, no molecular studies have yet yielded consistent information that is ready to be incorporated into clinical practice. We reviewed the current literature on the molecular biology of prostate cancer and analyzed different potential tumor markers according to the classical concepts of oncogenes, suppressor genes, and the more modern concepts of genes involved in detoxification or inflammatory pathways of cancer progression. This review aims to identify trends in PC research and suggests potential clinical applications for diagnosis, prognosis, prevention and treatment.
Volume
26
Issue
1
First Page
25
Last Page
37
ISSN
0392-9078
Published In/Presented At
Vecchione, A., Gottardo, F., Gomella, L. G., Wildemore, B., Fassan, M.s, Bragantini, E., Pagano, F., & Baffa, R. (2007). Molecular genetics of prostate cancer: clinical translational opportunities. Journal of experimental & clinical cancer research : CR, 26(1), 25–37.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
17550130
Department(s)
Administration and Leadership
Document Type
Article