Targeted therapies in the management of metastatic bladder cancer.
Publication/Presentation Date
12-1-2007
Abstract
The management of metastatic urothelial carcinoma (UC) of the bladder is a common and complex clinical challenge. Despite the fact that UC is one of the most frequent tumors in the population, long term survival for metastatic disease remains low, and chemotherapy is curative for only a small minority of patients. UC is genetically heterogeneous, and it is surrounded by a complex tissue microenvironment. The problems of clinical practice in the field of metastatic bladder cancer have begun to stimulate translational research. Advances in the understanding of the molecular biology of urothelial cancer continue to contribute to the identification of molecular pathways upon which new therapeutic approaches can be targeted. New agents and strategies have recently been developed which can direct the most appropriate choice of treatment for advanced disease. A review of literature published on the targeted therapy for metastatic bladder cancer is presented, focusing on the molecular pathways shut down by the new therapeutic agents.
Volume
1
Issue
4
First Page
393
Last Page
406
ISSN
1177-5475
Published In/Presented At
Fassan, M., Trabulsi, E. J., Gomella, L. G., & Baffa, R. (2007). Targeted therapies in the management of metastatic bladder cancer. Biologics : targets & therapy, 1(4), 393–406.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19707309
Department(s)
Administration and Leadership
Document Type
Article