Role of testosterone in managing advanced prostate cancer.
Publication/Presentation Date
10-1-2012
Abstract
Androgen deprivation therapy is frequently used to treat patients with advanced prostate cancer. New therapies for metastatic castration-resistant prostate cancer have drawn increased attention to serum and intratumoral testosterone levels. The present review examines the role of testosterone in prostate cancer progression, discusses the nuances and potential pitfalls in measuring serum testosterone using available assays, and summarizes current data relevant to the arguments for and against achieving and maintaining the lowest possible testosterone levels during androgen deprivation therapy, including the adverse effects of such treatment. Incorporating this information, we have made recommendations incorporating testosterone evaluation and its effect on the clinical decision-making process.
Volume
80
Issue
4
First Page
754
Last Page
762
ISSN
1527-9995
Published In/Presented At
Rove, K. O., Debruyne, F. M., Djavan, B., Gomella, L. G., Koul, H. K., Lucia, M. S., Petrylak, D. P., Shore, N. D., Stone, N. N., & Crawford, E. D. (2012). Role of testosterone in managing advanced prostate cancer. Urology, 80(4), 754–762. https://doi.org/10.1016/j.urology.2012.05.006
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22795376
Department(s)
Administration and Leadership
Document Type
Article