microRNAs in colon cancer: a roadmap for discovery.

Authors

• Simona Rossi
• Antonio Fabio Di Narzo
• Pieter Mestdagh
• Bart Jacobs
• Fredrik T Bosman
• Bengt Gustavsson
• Bernard Majoie
• Arnaud Roth
• Jo Vandesompele
• Isidore Rigoutsos
• Mauro Delorenzi
• Sabine Tejpar

Publication/Presentation Date

9-21-2012

Abstract

Cancer omics data are exponentially created and associated with clinical variables, and important findings can be extracted based on bioinformatics approaches which can then be experimentally validated. Many of these findings are related to a specific class of non-coding RNA molecules called microRNAs (miRNAs) (post-transcriptional regulators of mRNA expression). The related research field is quite heterogeneous and bioinformaticians, clinicians, statisticians and biologists, as well as data miners and engineers collaborate to cure stored data and on new impulses coming from the output of the latest Next Generation Sequencing technologies. Here we review the main research findings on miRNA of the first 10 years in colon cancer research with an emphasis on possible uses in clinical practice. This review intends to provide a road map in the jungle of publications of miRNA in colorectal cancer, focusing on data availability and new ways to generate biologically relevant information out of these huge amounts of data.

Volume

586

Issue

19

First Page

3000

Last Page

3007

ISSN

1873-3468

Published In/Presented At

Rossi, S., Di Narzo, A. F., Mestdagh, P., Jacobs, B., Bosman, F. T., Gustavsson, B., Majoie, B., Roth, A., Vandesompele, J., Rigoutsos, I., Delorenzi, M., & Tejpar, S. (2012). microRNAs in colon cancer: a roadmap for discovery. FEBS letters, 586(19), 3000–3007. https://doi.org/10.1016/j.febslet.2012.07.048

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

23166923

Department(s)

Administration and Leadership

Document Type

Article