A Clinician's Guide to Next Generation Imaging in Patients With Advanced Prostate Cancer (RADAR III).

Authors

• E David Crawford
• Phillip J Koo
• Neal Shore
• Susan F Slovin
• Raoul S Concepcion
• Stephen J Freedland
• Leonard G Gomella
• Lawrence Karsh
• Thomas E Keane
• Paul Maroni
• David Penson
• Daniel P Petrylak
• Ashley Ross
• Vlad Mouraviev
• Robert E Reiter
• Chaitanya Divgi
• Evan Y Yu

Publication/Presentation Date

4-1-2019

Abstract

PURPOSE: The advanced prostate cancer therapeutic landscape has changed dramatically in the last several years, resulting in improved overall survival of patients with castration naïve and castration resistant disease. The evolution and development of novel next generation imaging techniques will affect diagnostic and therapeutic decision making. Clinicians must navigate when and which next generation imaging techniques to use and how to adjust treatment strategies based on the results, often in the absence of correlative therapeutic data. Therefore, guidance is needed based on best available information and current clinical experience.

MATERIALS AND METHODS: The RADAR (Radiographic Assessments for Detection of Advanced Recurrence) III Group convened to offer guidance on the use of next generation imaging to stage prostate cancer based on available data and clinical experience. The group also discussed the potential impact of next generation imaging on treatment options based on earlier detection of disease.

RESULTS: The group unanimously agreed that progression to metastatic disease is a seminal event for patient treatment. Next generation imaging techniques are able to detect previously undetectable metastases, which could redefine the phases of prostate cancer progression. Thus, earlier systemic or locally directed treatment may positively alter patient outcomes.

CONCLUSIONS: The RADAR III Group recommends next generation imaging techniques in select patients in whom disease progression is suspected based on laboratory (biomarker) values, comorbidities and symptoms. Currently

Volume

201

Issue

4

First Page

682

Last Page

692

ISSN

1527-3792

Published In/Presented At

Crawford, E. D., Koo, P. J., Shore, N., Slovin, S. F., Concepcion, R. S., Freedland, S. J., Gomella, L. G., Karsh, L., Keane, T. E., Maroni, P., Penson, D., Petrylak, D. P., Ross, A., Mouraviev, V., Reiter, R. E., Divgi, C., Yu, E. Y., & RADAR III Group (2019). A Clinician's Guide to Next Generation Imaging in Patients With Advanced Prostate Cancer (RADAR III). The Journal of urology, 201(4), 682–692. https://doi.org/10.1016/j.juro.2018.05.164

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

30077557

Department(s)

Administration and Leadership

Document Type

Article