Design and rationale of the URGENT Dyspnea study: an international, multicenter, prospective study.
Publication/Presentation Date
1-1-2008
Abstract
BACKGROUND: Dyspnea is a key target in both clinical management and clinical trials of acute heart failure syndromes and its relief important to patients, clinicians, investigators, and regulatory approval agencies. Despite its importance, the impact of early therapy on dyspnea is not well known. The severity of dyspnea may also be influenced by the conditions under which it is measured (ie, sitting up or lying down). URGENT Dyspnea (Ularitide Global Evaluation in Acute Decompensated Heart Failure) is a prospective multicenter study designed to address these issues.
METHODS AND RESULTS: Consenting adult patients with dyspnea secondary to acute heart failure syndromes are eligible. Patients must be interviewed within one hour of first physician evaluation, typically in an emergency department or acute care setting, with dyspnea assessed by the patient using both a 5-point Likert scale and 10-point visual analog scale in the sitting (60 degrees) and then supine (20 degrees ) position if symptomatically able. Improvement of dyspnea by change in Likert and visual analog scale scores at 6 h is the primary endpoint.
CONCLUSIONS: Timing of dyspnea measurement and the conditions under which it is measured may influence dyspnea severity and this may have significant implications for future acute heart failure syndromes clinical trial design that target dyspnea.
Volume
15
Issue
4
First Page
299
Last Page
303
ISSN
1536-3686
Published In/Presented At
Pang, P. S., Tavares, M., Collins, S. P., Cleland, J. G., Hollander, J., Nieminen, M., Miller, C., Courtney, D. M., Kirk, J. D., Masip, J., Parkhomenko, A., Macarie, C., Peacock, W. F., Spinar, J., Nowak, R., Raev, D., Storrow, A. B., Spisak, V., Hamdy, A., Mebazaa, A., … URGENT Investigators (2008). Design and rationale of the URGENT Dyspnea study: an international, multicenter, prospective study. American journal of therapeutics, 15(4), 299–303. https://doi.org/10.1097/MJT.0b013e31816b436e
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18645329
Department(s)
Administration and Leadership
Document Type
Article