MicroRNA 125a and its regulation of the p53 tumor suppressor gene.

Authors

• Yingjie Zhang
• Jin-Song Gao
• Xiaoli Tang
• Lynne D Tucker
• Peter Quesenberry
• Isidore Rigoutsos
• Bharat Ramratnam

Publication/Presentation Date

11-19-2009

Abstract

MicroRNA (miRNA) are a class of non-coding RNA that suppress gene expression by degradation or translational inhibition of target RNA. Several miRNA have been shown to target oncogenes and recently miRNA-125b was shown to translationally and transcriptionally inhibit the p53 gene. Here, we show that an additional isomer of miRNA-125 (miRNA-125a) translationally arrests mRNA of the p53 tumor suppressor gene. The basis of this activity is the high degree of sequence homology between the seed sequence of miR-125a and the 3'-UTR of p53. Our findings add miRNA-125a to the growing list of miRNA with oncogenic targets.

Volume

583

Issue

22

First Page

3725

Last Page

3730

ISSN

1873-3468

Published In/Presented At

Zhang, Y., Gao, J. S., Tang, X., Tucker, L. D., Quesenberry, P., Rigoutsos, I., & Ramratnam, B. (2009). MicroRNA 125a and its regulation of the p53 tumor suppressor gene. FEBS letters, 583(22), 3725–3730. https://doi.org/10.1016/j.febslet.2009.10.002

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

19818772

Department(s)

Administration and Leadership

Document Type

Article