The emerging roles of GPRC5A in diseases.
Publication/Presentation Date
1-1-2014
Abstract
The 'Retinoic Acid-Inducible G-protein-coupled receptors' or RAIG are a group comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D. As the name implies, their expression is induced by retinoic acid but beyond that very little is known about their function. In recent years, one member, GPRC5A, has been receiving increasing attention as it was shown to play important roles in human cancers. As a matter of fact, dysregulation of GPRC5A has been associated with several cancers including lung cancer, breast cancer, colorectal cancer, and pancreatic cancer. Here we review the current state of knowledge about the heterogeneity and evolution of GPRC5A, its regulation, its molecular functions, and its involvement in human disease.
Volume
1
Issue
12
First Page
765
Last Page
776
ISSN
2331-4737
Published In/Presented At
Zhou, H., & Rigoutsos, I. (2014). The emerging roles of GPRC5A in diseases. Oncoscience, 1(12), 765–776. https://doi.org/10.18632/oncoscience.104
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
25621293
Department(s)
Administration and Leadership
Document Type
Article