Roles of mitochondrial genetics in cancer metastasis.

Authors

• Danny R Welch
• Christian Foster
• Isidore Rigoutsos

Publication/Presentation Date

12-1-2022

Abstract

The contributions of mitochondria to cancer have been recognized for decades. However, the focus on the metabolic role of mitochondria and the diminutive size of the mitochondrial genome compared to the nuclear genome have hindered discovery of the roles of mitochondrial genetics in cancer. This review summarizes recent data demonstrating the contributions of mitochondrial DNA (mtDNA) copy-number variants (CNVs), somatic mutations, and germline polymorphisms to cancer initiation, progression, and metastasis. The goal is to summarize accumulating data to establish a framework for exploring the contributions of mtDNA to neoplasia and metastasis.

Volume

8

Issue

12

First Page

1002

Last Page

1018

ISSN

2405-8025

Published In/Presented At

Welch, D. R., Foster, C., & Rigoutsos, I. (2022). Roles of mitochondrial genetics in cancer metastasis. Trends in cancer, 8(12), 1002–1018. https://doi.org/10.1016/j.trecan.2022.07.004

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

35915015

Department(s)

Administration and Leadership

Document Type

Article