Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer.
Publication/Presentation Date
12-24-2021
Abstract
Understanding metabolic and immune regulation inherent to patient populations is key to improving the radiation response for our patients. To date, radiation therapy regimens are prescribed based on tumor type and stage. Patient populations who are noted to have a poor response to radiation such as those of African American descent, those who have obesity or metabolic syndrome, or senior adult oncology patients, should be considered for concurrent therapies with radiation that will improve response. Here, we explore these populations of breast cancer patients, who frequently display radiation resistance and increased mortality rates, and identify the molecular underpinnings that are, in part, responsible for the radiation response and that result in an immune-suppressive tumor microenvironment. The resulting immune phenotype is discussed to understand how antitumor immunity could be improved. Correcting nutrient deficiencies observed in these populations should be considered as a means to improve the therapeutic index of radiation therapy.
Volume
23
Issue
1
ISSN
1422-0067
Published In/Presented At
Shastri, A. A., Lombardo, J., Okere, S. C., Higgins, S., Smith, B. C., DeAngelis, T., Palagani, A., Hines, K., Monti, D. A., Volpe, S., Mitchell, E. P., & Simone, N. L. (2021). Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer. International journal of molecular sciences, 23(1), 175. https://doi.org/10.3390/ijms23010175
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
35008602
Department(s)
Administration and Leadership
Document Type
Article