Endogenous opiates in the mediation of early meal-induced jejunal absorption of water and electrolytes.
Publication/Presentation Date
1-1-1989
Abstract
The purpose of this study was to investigate the role of endogenous opiates in mediating meal-stimulated jejunal absorption. Jejunal Thiry-Vella loops, 25 cm long, were studied in awake conditioned dogs, using luminal perfusion with carbon-14 polyethylene glycol. Fluxes of water, sodium, and chloride were calculated every 15 minutes over a 1-hour basal period, followed by a 3-hour experimental period. The animals were divided into four groups: control, naloxone, meal, and meal plus naloxone. In the control and naloxone groups, the fluxes did not change over the 4-hour observation period. Meal alone immediately stimulated the absorption of water and electrolytes in the Thiry-Vella loop (p less than 0.05). The addition of naloxone infusion to the meal stimulus resulted in significantly reduced absorption during the first hour after the meal (p less than 0.05). We concluded that endogenous opiates play a role in meal-stimulated jejunal absorption.
Volume
157
Issue
1
First Page
27
Last Page
32
ISSN
0002-9610
Published In/Presented At
Bastidas, J. A., Yeo, C. J., Schmieg, R. E., Jr, & Zinner, M. J. (1989). Endogenous opiates in the mediation of early meal-induced jejunal absorption of water and electrolytes. American journal of surgery, 157(1), 27–32. https://doi.org/10.1016/0002-9610(89)90415-7
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2910124
Department(s)
Administration and Leadership
Document Type
Article