Meal-stimulated canine jejunal ionic absorption. Effect of direct jejunal meal delivery and premeal intravenous hydration.
Publication/Presentation Date
6-1-1992
Abstract
The ingestion of a meal stimulates water and ion absorption from the small intestine. The administration of nutrient substances directly to the small bowel can cause dumping symptoms, with intraluminal fluid accumulation and relative systemic hypovolemia. This study compared the effect of oral versus direct jejunal meal delivery on jejunal water and ion absorption, with and without premeal intravenous saline infusion. Jejunal absorption studies (N = 40) were performed on dogs with 25 cm proximal jejunal Thiry-Vella fistulas and feeding jejunostomies. Luminal perfusion with [14C]PEG was used to calculate fluxes of water and electrolytes. Five groups were randomly studied: (1) intravenous 0.9% saline alone, (2) oral meal alone, (3) intravenous 0.9% saline plus oral meal, (4) jejunal meal alone, and (5) intravenous 0.9% saline plus jejunal meal. Hydration status was assessed hourly by measurement of hematocrit. Water and electrolyte absorption was significantly stimulated by both oral and jejunal meal delivery (P less than 0.01). Intravenous saline hydration significantly reduced the hematocrit (P less than 0.05) but did not alter the proabsorptive response to an oral or jejunal meal. In conclusion, a postprandial signal for proximal jejunal water and electrolyte absorption was stimulated equally by orally or jejunally administered nutrients and was not affected by premeal hydration. These data support the hypothesis that the proabsorptive signal that stimulates water and ion absorption is an enteroenteric phenomenon originating from the small intestine, without implicating pathophysiologic events such as hypovolemia or dumping.
Volume
37
Issue
6
First Page
842
Last Page
848
ISSN
0163-2116
Published In/Presented At
Anthone, G. J., Mavrophilipos, Z. V., Zinner, M. J., Wang, B. H., Orandle, M. S., & Yeo, C. J. (1992). Meal-stimulated canine jejunal ionic absorption. Effect of direct jejunal meal delivery and premeal intravenous hydration. Digestive diseases and sciences, 37(6), 842–848. https://doi.org/10.1007/BF01300381
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
1587188
Department(s)
Administration and Leadership
Document Type
Article