A common antigenic determinant found in two functionally unrelated toxins.
Publication/Presentation Date
10-1-1984
Abstract
The heat-stable enterotoxin ST Ib produced by enterotoxigenic E. coli strains shares a sequence homology with the sea snail neurotoxin, conotoxin GI. Rabbit antisera were raised against synthetic analogs of these toxins and to a six-residue peptide representing the region common to both toxins. Results from enzyme-linked immunosorbent assays indicate that the homologous region of both toxins represents part of their antigenic site. The lack of cross-reactivity exhibited by the six-residue common domain with serum directed against either toxin suggests that this region probably retains a similar conformation in the intact toxins but not in the isolated fragment.
Volume
160
Issue
4
First Page
1253
Last Page
1258
ISSN
0022-1007
Published In/Presented At
Gariepy, J., O'Hanley, P., Waldman, S. A., Murad, F., & Schoolnik, G. K. (1984). A common antigenic determinant found in two functionally unrelated toxins. The Journal of experimental medicine, 160(4), 1253–1258. https://doi.org/10.1084/jem.160.4.1253
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
6207263
Department(s)
Administration and Leadership
Document Type
Article