The guanylyl cyclase family of natriuretic peptide receptors.
Publication/Presentation Date
1-1-1999
Abstract
Guanylyl cyclases are cytoplasmic and membrane-associated enzymes that catalyze the conversion of GTP to cyclic GMP, an intracellular signaling molecule. Molecular cloning has identified a multigene family encoding both soluble and particulate forms of the enzymes. Diffusible agents such as nitric oxide and carbon monoxide activate the soluble guanylyl cyclases. The particulate members of the family share a characteristic domain arrangement, with a single transmembrane span separating a variable extracellular ligand-binding domain from a conserved intracellular regulatory and cyclase catalytic domain. Seven members of the particulate guanylyl cyclase family have been identified, and they include the receptors for natriuretic peptides and Escherichia coli heat-stable enterotoxin. Recently, animal models have been developed to study the role of natriuretic peptides and their guanylyl cyclase-coupled receptors in renal and cardiovascular physiology.
Volume
57
First Page
123
Last Page
151
ISSN
0083-6729
Published In/Presented At
Schulz, S., & Waldman, S. A. (1999). The guanylyl cyclase family of natriuretic peptide receptors. Vitamins and hormones, 57, 123–151. https://doi.org/10.1016/s0083-6729(08)60642-1
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
10232048
Department(s)
Administration and Leadership
Document Type
Article